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Posts Tagged ‘gluten challenge’

Notes on New Research and New Tests on Celiac Disease

Monday, August 24th, 2015

Physicians around the world are now more aware of the likely- hood of Celiac Disease.  Some of the classic symptoms the research suggests as guidelines are: weight loss, diarrhea, mal-absorption, and short statue.  The testing by the physicians should show a higher anti-tissue transglutaminase antibody (tTG).  The testing should also show a positive anti-endomysial antibody (EMA) blood test.  The individual should be a heredity risk for the disease, having HLADQ2 or HlADQ8 genes.  This is great except that still Celiac Disease does not have a standard for defining a positive or negative Celiac Disease Blood test.  Most lab professionals vary in their testing and results.  This causes confusion with the physicians and patients.  In the end it will lead back to “Gluten elimination” and ”Gluten challenge”.  With infants this type of testing and elimination is easy, not so with older children and adults.

An exiting new test on the horizon is a new urine test for Celiac Disease.  This test looks for gluten peptides in the urine.  The correlation of gluten peptides in mucosal damage was found higher than other markers available on the market.  According to the researchers as low as 50 mg of gluten peptides can be detected in the urine.  This test is so much easier to do and easier on the patient than a small intestinal biopsy.  Hopefully this test will be available to the public at large for self testing at some point.  While the stool test is accurate, the urine test is accurate and less messy.